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Oxygen-15 labelled water has been prepared at high specific activities (> 100 mCi/ml) by nuclear recoil techniques available for use after 1 min from EOB. Radiogenic oxygen-15 atoms generated in a cyclotron by the 14N(d, n)15O reaction, are allowed to react directly with molecular hydrogen in the gas phase to produce labelled “carrier-free” H215O which can be used for biomedical purposes.
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Ruiz et al. (1978) studied this question.
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