Why the study?
The mechanisms of action underlying the cardioprotective properties of kaempferol in cardiac injury remain unclear.
Kaempferol is a flavonoid with potential cardioprotective properties in cardiac injury models, though its exact mechanisms require further elucidation.
Supports expanded preclinical testing of kaempferol in cardiac injury; leaves open clinical translation without human data.
Cardiac diseases, such as myocardial infarction and heart failure, have become a major clinical problem globally. The accumulating data demonstrate that bioactive compounds with antioxidant and anti-inflammatory properties have favorable effects on clinical problems. Kaempferol is a flavonoid found in various plants; it has demonstrated cardioprotective properties in numerous cardiac injury models. This review aims to collate updated information regarding the effects of kaempferol on cardiac injury. Kaempferol improves cardiac function by alleviating myocardial apoptosis, fibrosis, oxidative stress, and inflammation while preserving mitochondrial function and calcium homeostasis. However, the mechanisms of action of its cardioprotective properties remain unclear; therefore, elucidating its action could provide insight into directions for future studies.
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Kamisah et al. (2023) studied this question.
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