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Direct Electrical Stimulation (DES) is a powerful method for establishing the critical function(s) of brain regions. Yet, behavioral effects elicited by DES, especially in the human association cortex, can be caused by disturbance of connected brain regions beyond the stimulation site [1]. Assessing the spatial distribution and the extent of these remote effects is therefore fundamental for understanding cortical networks underlying brain function and behavior. This question has generally been addressed either through spontaneous intracranial EEG (iEEG) recordings during DES, or brain connectivity measures (cortico-cortical evoked potentials or CCEP, functional/structural connectivity) collected independently [2].
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Angelini et al. (2024) studied this question.
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