Why the study?
Methadone carries an FDA Boxed Warning for QTc prolongation, but guidelines have limited pediatric applicability and electrophysiologic safety data in children are scarce.
Does methadone prolong the corrected QT interval in critically ill children?
Does methadone prolong the corrected QT interval in critically ill children?
Methadone does not significantly prolong the corrected QT interval in critically ill children, suggesting it can be safely used, though patients with structural heart disease may warrant closer monitoring.
Methadone appears safe for QTc in PICU children; leaves open need for prospective trials before guideline changes.
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Friedman et al. (2020) studied this question.
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