Mechanism of baroreceptor adaptation in dogs: attenuation of adaptation by the K+ channel blocker 4‐aminopyridine.

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Population

Anaesthetized dogs (vascularly isolated carotid sinus model)

Comparison

4-aminopyridine and Ouabain vs Control conditions (adaptation without drug)

Design

Preclinical

Follow-up

5 minutes (duration of pressure step)

Authors

Discussion

Does not support clinical translation; leaves open mechanistic role of K+ currents in human baroreflex regulation.

Population

Anaesthetized dogs (vascularly isolated carotid sinus model)

Intervention

4-aminopyridine (4-AP) (10^-5 and 10^-4 M) and Ouabain (5 x 10^-7 - 10^-6 M)

Comparator

Control conditions (adaptation without drug)

Outcome

Baroreceptor activity (multi- and single fibre recordings) during step increases in carotid sinus pressuresurrogate

Activation of a 4-AP-sensitive K+ current contributes significantly to baroreceptor adaptation in dogs, independent of Na+,K+-ATPase.

Chapleau et al. (1993) studied this question.

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