The Choroid Plexus: Immunologic Injury and Disease

Editorial1 July 1974The Choroid Plexus: Immunologic Injury and DiseaseRAWLE M. MCINTOSH, M.D., MICHAEL M. KOSS, M.D.RAWLE M. MCINTOSH, M.D.Search for more papers by this author, MICHAEL M. KOSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last few years it has become apparent that immunologic mechanisms are involved in cell and tissue injury in a variety of human diseases. Two immunopathogenic processes have been recognized and well defined in injury to vascular membranes in man and experimental animals. Several studies of diffuse glomerular diseases in man and laboratory animals have helped to clarify these mechanisms. The best evidence of an immunologic pathogenesis in man is available in systemic lupus erythematosus and in Goodpasture's syndrome, where two different immunological processes have been implicated in the damage to the glomerular capillary: circulating antigen-antibody complexes in lupus...References1. KOFFLERSCHURKUNKEL DPH: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-624, 1967 CrossrefMedlineGoogle Scholar2. LERNERGLASSOCKDIXON RRF: The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. Ibid., pp. 989-1004 Google Scholar3. MAXWELLPEASE DD: The electron microscopy of the choroid plexus. J Biophys Biochem Cytol 2:467-474, 1956 CrossrefMedlineGoogle Scholar4. WISLOCKLADMAN GA: The fine structure of the mammalian choroid plexus, in Cerebrospinal Fluid. London, J & A Churchill, Ltd., 1958, pp. 55-75 Google Scholar5. 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Am J Physiol 52:483-497, 1920 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAWLE M. MCINTOSH, M.D.; MICHAEL M. KOSS, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutoantibodies to Nervous System Tissue in Human and Murine Systemic Lupus ErythematosusMechanisms of the Immune-Mediated VasculitidesPseudotumor cerebri as a cardinal sign of the polyangiitis overlap syndromeThe neuropsychiatric manifestations of systemic lupus erythematosus: An overviewInteractions of dietary proteins with the mucosal immune system as a component of safety evaluationLesões de plexo coróide na esquistossomose mansônicaNeurological complications of connective tissue and other “collagen-vascular” diseasesAbnormalities of cerebrospinal fluid amino acids in patients with the Guillain-Barre syndrome.The Role of Immune Complexes in the Pathogenesis of Necrotizing VasculitidesZur Therapie der hochgradigen Linksherzinsuffizienz mit Hypotension: Kombinierte Dauerinfusion mit Nitroglyzerin und DopaminCentral nervous system involvement in systemic lupus erythematosus: A review of neuropathologic findings in 57 cases, 1955–1977The choroid plexus in CNS involvement of systemic lupus erythematosus 1 July 1974Volume 81, Issue 1Page: 111-113KeywordsAntigensCapillariesLupus erythematosusPathogenesisResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...