The primary antifungal action of polygodial comes in part from its ability to function as a nonionic surfactant, disrupting the lipid−protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial, presumably caused by inhibition of the plasma membrane H + -ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.
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Kubo et al. (2001) studied this question.
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