Angioimmunoblastic T-cell lymphoma associated with myeloid neoplasms: a case report and literature review supporting a shared clonal origin

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Key Points

This study aims to explore the potential shared clonal origin of angioimmunoblastic T-cell lymphoma and associated myeloid neoplasms.
Case report of an 87-year-old male with concurrent AITL and MDS-IB2.
Utilized skin biopsy and bone marrow aspirate combined with flow cytometry for diagnosis.
Performed targeted next-generation sequencing on lymphoid and myeloid samples.
Both samples exhibited shared pathogenic mutations IDH2 p.R140Q and ASXL1 p.R1415X.
Unique mutations found included TP53, CIITA, and NOTCH1 in lymphoid lesions, and SRSF2, STAG2, and BCOR in myeloid lesions.
Molecular evidence confirmed both tumors originated from a single hematopoietic stem progenitor cell carrying early clonal mutations.

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Case report demonstrates shared clonal origin of angioimmunoblastic T-cell lymphoma and myeloid neoplasms, suggesting underlying genetic links.

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Yang et al. (2026) studied this question.

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