What question did this study set out to answer?

To assess the hemodynamic and mechanical effects of left ventricular and biventricular pacing in an experimental canine model of left bundle branch block.

June 1, 2002AJP Heart and Circulatory Physiology

Left ventricular resynchronization therapy in a canine model of left bundle branch block

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Why the study?

Does left ventricular and biventricular stimulation improve hemodynamics and wall motion in a canine model of left bundle branch block?

Population

9 anesthetized dogs with left bundle branch block induced by radiofrequency ablation.

Comparison

Left ventricular and biventricular stimulation… vs Right ventricular stimulation, and baseline…

Design

Preclinical

Authors

LLLili LiuGuangdong Medical College BTBruce TockmanUniversity of Minnesota SGSteven GirouardElectrophysiology

Discussion

Member takes

Implication

Supports CRT mechanisms in experimental LBBB; leaves open translation to human pacing strategies.

Key Points

To assess the hemodynamic and mechanical effects of left ventricular and biventricular pacing in an experimental canine model of left bundle branch block.
Induced left bundle branch block via radiofrequency ablation in an anesthetized canine model.
Measured left ventricular dP/dt and aortic pulse pressure across right ventricular, left ventricular, and biventricular stimulation with four atrioventricular delays in 6 dogs.
Assessed septal and left ventricular posterior wall motion using M-mode echocardiography before ablation, after ablation, and during left ventricular pacing in 3 dogs.
Following ablation, left ventricular and biventricular pacing maximally increased left ventricular dP/dt by 16% and pulse pressure by 7% (P < 0.001), whereas right ventricular pacing produced minimal improvement.
Paradoxical septal wall motion caused by left bundle branch block was corrected by left ventricular stimulation.

Structured PICO

Does left ventricular and biventricular stimulation improve hemodynamics and wall motion in a canine model of left bundle branch block?

Population

9 anesthetized dogs (6 for hemodynamics, 3 for echocardiography) with left bundle branch block (LBBB) induced by radiofrequency ablation.

Intervention

Left ventricular (LV) and biventricular (BV) stimulation combined with four atrioventricular delays.

Comparator

Right ventricular (RV) stimulation, and baseline states (normal sinus rhythm before ablation, LBBB without stimulation).

Outcome

Left ventricular pressure derivative over time (dP/dt) and aortic pulse pressure (PP).surrogate

In a canine model of LBBB, left ventricular and biventricular pacing improved hemodynamics and corrected paradoxical septal motion, supporting the mechanism of cardiac resynchronization therapy.

Cite This Study

Liu et al. (2002) studied this question.

synapsesocial.com/papers/6a798cc635e7b6bcc688ff53 https://doi.org/10.1152/ajpheart.00684.2001

Topics

Echocardiography

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Left ventricular resynchronization therapy in a canine model of left bundle branch block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left ventricular resynchronization therapy in a canine model of left bundle branch block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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