We dynamically model the full ionic current signature of micron-sized colloids passing through microcapillaries in silico for the first time. Our novel computer simulation allows free adjustment of all relevant experimental parameters such as the geometry of the used orifice, noise sources, external applied pressure or voltage, and the charge of the particles passing through the channel. We demonstrate that our algorithm correctly describes the experimentally observed signals in our recently introduced microcapillary based Coulter counters. Finally, we quantitatively investigate the influence of DNA-functionalized particles on the signal amplitude as a function of salt concentration and particle size.
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Stober et al. (2009) studied this question.