Resistance of Micrococci (Staphylococci) to Antibiotics

Editorial1 April 1955RESISTANCE OF MICROCOCCI (STAPHYLOCOCCI) TO ANTIBIOTICSPAUL W. CLOUGHPAUL W. CLOUGHAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-4-954 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment of severe staphylococcal infections has always presented difficult problems which have by no means been eliminated by the advent of antibacterial drugs. The sulfonamides furnished relatively little help, although sulfathiazole for a time proved effective in many cases of staphylococcal infection of the urinary passages and occasionally in generalized infections.The advent of penicillin, however, apparently opened up a new era when it was found that these organisms were almost uniformly sensitive to penicillin and that the drug was highly effective clinically. The immediate result, when adequate quantities of penicillin were available, was a marked reduction in mortality and...1 Spink WW: Staphylococcal infections and the problem of antibiotic-resistant staphylococci, Arch. Int. Med. 94: 167-196, 1954. CrossrefGoogle Scholar2 Spink WW: Clinical and biological significance of penicillin-resistant staphylococci, including observations with streptomycin, Aureomycin, chloramphenicol and Terramycin, J. Lab. and Clin. Med. 37: 278-293, 1951. MedlineGoogle Scholar3 Prissick FH: Antibiotic-resistant staphylococci and related infections, Am.. J. M. Sc. 225: 299-319, 1953. (Good general review.) MedlineGoogle Scholar4 KnightHolzer VAR: Quoted by Spink,1 p. 181. Google Scholar5 Hirsh HL: Organisms resistant to penicillin obtained from patients, Arch. Int. Med. 82: 310-318, 1948. CrossrefGoogle Scholar6 KnightHolzer VAR: Studies on staphylococci from hospital patients. I. Predominance of strains of Group III phage patterns which are resistant to multiple antibiotics, J. Clin. Investigation 33: 1190-1198, 1954. CrossrefMedlineGoogle Scholar7 RountreeThomson PMEF: Incidence of antibiotic-resistant staphylococci in a hospital, Lancet 2: 262-265, 1952. CrossrefMedlineGoogle Scholar8 RountreeBarbour PMRH: Staphylococcus pyogenes in new-born babies in a maternity hospital, M. J. Australia 1: 525, 1950. CrossrefMedlineGoogle Scholar9 Martyn G: Staphylococci in the new-born, Brit. M. J. 1: 710, 1949. CrossrefMedlineGoogle Scholar10 Barber M: Infection by penicillin-resistant staphylococci, Lancet 2: 641, 1948. CrossrefMedlineGoogle Scholar11 DowlingLepperJackson HFMHGG: Observations on the epidemiological spread of antibiotic-resistant staphylococci with measurements of the changes in sensitivity to penicillin and Aureomycin, Am. J. Pub. Health 43: 860-868, 1953. CrossrefGoogle Scholar12 Altemeier WA: Critical re-evaluation of antibiotic therapy in surgery, J. A. M. A. 157: 305-309, 1955. CrossrefMedlineGoogle Scholar13 FinlandHaight MTH: Antibiotic resistance of pathogenic staphylococci. Study of five hundred strains isolated at Boston City Hospital from October 1951 to February 1952, Arch. Int. Med. 91: 143-158, 1953. CrossrefGoogle Scholar14 Jackson GG: Terramycin therapy of pneumonia; clinical and bacteriological studies in 91 cases, Ann. Int. Med. 35: 1175-1202, 1951. LinkGoogle Scholar15 Speare GS: Staphylococcus pseudomembranous enterocolitis, a complication of antibiotic therapy, Am. J. Surg. 88: 523-534, 1954. CrossrefMedlineGoogle Scholar16 DearingHeilman WHFR: Micrococcic (staphylococcic) enteritis as a complication of antibiotic therapy, Proc. Staff Meet., Mayo Clin. 28: 121, 1952. Google Scholar17 HerrellMartin WEWJ: Erythromycin for infections due to Micrococcus pyogenes , J. A. M. A. 152: 1601, 1953. CrossrefMedlineGoogle Scholar18 DowlingLepperJackson HFMHGG: Clinical significance of antibiotic-resistant bacteria, J. A. M. A. 157: 327-331, 1955. CrossrefMedlineGoogle Scholar19 Howe GW: Postoperative wound infections due to Staphylococcus aureus , New England J. Med. 251: 411-417, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL W. CLOUGH PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanging Patterns of Susceptibility of Common Bacterial Pathogens to Antimicrobial AgentsMAXWELL FINLAND, M.D., M.A.C.P.STAPHYLOCOCCAL SEPTICEMIA WITH RECURRENT SPONTANEOUS PNEUMOTHORAX*ALBERT SCHWEICH, M.D., JOSEPH FIERSTEIN, M.D.Fifteen years' experience with staphylococcus septicemia in a large city hospitalManagement of postoperative diarrheas and infectionsEmergence of Antibiotic-Resistant Bacteria 1 April 1955Volume 42, Issue 4Page: 954-959KeywordsAntibioticsDrugsMortalityPenicillinStaphylococcal infectionSulfonamideUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 April 1955 PDF downloadLoading ...