Concept proposes regional limb perfusion to stabilize ischemic limbs in individuals not eligible for revascularization, suggesting potential for reducing amputations.
Critical limb ischemia (CLI) remains a major cause of lower-limb amputation in patients with diabetes, particularly among individuals who are not candidates for revascularization [1,2]. Inspired by organ-support therapies such as hemodialysis and extracorporeal membrane oxygenation (ECMO), this manuscript proposes a hospital-based, dialysis-inspired regional limb perfusion support concept aimed at temporarily stabilizing threatened ischemic limbs. The proposed system involves placing the affected limb within a controlled perfusion chamber designed to enhance local oxygen delivery, optimize perfusion pressure, and modulate the metabolic microenvironment. This approach is conceptual and intended to expand the therapeutic window and delay tissue necrosis.
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Andya Mansoori (2026) studied this question.
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