Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis

CONCLUSION: The results of our study demonstrated the association between the single nucleotide polymorphisms (SNPs) of GATA-3 and allergic rhinitis (AR). OBJECTIVE: AR is considered to be controlled by T-helper type 2 (Th2) cells. GATA-3 is the crucial transcription factor controlling the differentiation and function of Th2 cells. We aimed to evaluate the association between the SNPs of GATA-3 and AR. SUBJECTS AND METHODS: GATA-3 SNPs in 109 AR patients and 112 healthy controls in China were detected with restriction fragment length polymorphism. RESULTS: The genotypes at rs1269486 were GG, GA, and AA, and the genotypes at rs2229360 were CC, CT, and TT. The frequency of the G allele in the patient group was significantly higher than that in the control group (p<0.01), while the frequency of the A allele in the patient group was significantly lower than that in the control group (p<0.01). Meanwhile, the haplotype frequency of GC at the two loci in the patient group was significantly higher than that in the control group (p<0.01), and the haplotype frequency of AC in the patient group was significantly lower than that in the control group (p<0.01).