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This editorial highlights the pathophysiological importance of coronary microvascular dysfunction in sepsis and dengue shock, emphasizing the need for targeted therapeutic research.
[No abstract - showing first paragraph]The coronary arterial system consists of a continuous network of functionally distinct vessels of decreasing size. The epicardial arteries (>500 μm) have primarily a conductance function and, therefore, physiologically offer minimal resistance to flow. The microcirculation, including pre-arterioles (100 to 500 μm) and arterioles (<100 μm), on the other hand, is the main active determinant of resistance within the coronary tree, responsible for the metabolic regulation of regional blood flow to the myocardium.
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Argirò et al. (2020) conducted an editorial in Sepsis and coronary microvascular dysfunction.
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