Key result
Severe hyperkalemia and diabetic ketoacidosis unmasked a Brugada pattern in a patient with a family history of sudden infant death syndrome, suggesting a potential genetic link.
Case Report (n=1)
Recognizing SIDS as part of the diagnostic criteria for Brugada Syndrome could help identify families susceptible to sudden cardiac death.
May support including SIDS family history in Brugada evaluation; hypothesis-generating for genetic links and requires validation.
Brugada Syndrome (BrS) is a cardiac disorder characterized by incomplete right bundle-branch block and ST elevations in the anterior precordial leads especially V1 -V3 , associated with an increased risk for sudden cardiac death (SCD) in young adults. Our case describes a patient with family history of sudden infant death syndrome (SIDS) who presented with a Brugada pattern unmasked by severe hyperkalemia and diabetic ketoacidosis. Several studies have concluded there may be a genetic link among SIDS, SDC, and BrS resulting from mutations in cardiac ion channel-related genes. Recognizing SIDS as part of the diagnostic criteria for BrS would help us identifying a significant number of families susceptible to develop SCD (as well as SIDS).
No takes yet. Share an insight, caveat, or question.
Franco et al. (2013) conducted a case report in Brugada Syndrome (n=1). Severe hyperkalemia and diabetic ketoacidosis was evaluated. Severe hyperkalemia and diabetic ketoacidosis unmasked a Brugada pattern in a patient with a family history of sudden infant death syndrome, suggesting a potential genetic link.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: