A novel benzoic acid‐promoted intermolecular 1,3‐dipolar cycloaddition reaction has been developed for the one‐pot construction of biologically important pyrrolo[2, 1‐ a ]isoquinolines. This metal‐free reaction between dipolarophiles and in situ‐generated azomethine ylides avoids the pre‐preparation of N‐substituted substrates and allows for the efficient formation of one C−N bond and two C−C bonds.
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Zheng et al. (2017) studied this question.
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