Key result
Pulmonary artery banding alters right heart proteomes, specifically downregulating right atrial metabolic pathways.
Why the study?
Although right heart failure involves both right atrial and right ventricular dysfunction, the proteomic response of these distinct chambers to pressure overload remains undefined.
Proteomic profiling in a porcine model of right heart failure reveals that while the right atrium and right ventricle share several metabolic and structural alterations, the right atrium exhibits unique deficits in the TCA cycle and BCAA metabolism, highlighting potential chamber-specific therapeutic targets.
Distinct RA-RV proteomic responses to pressure overload; hypothesis-generating for chamber-specific therapies in right heart failure.
Right heart failure is due to both right atrial and right ventricular dysfunction. While the two chambers are distinct, the proteomic response to pressure overload is undefined. Here, we used quantitative proteomics to evaluate changes in both chambers in pulmonary artery banded pigs. We found common alterations in oxidative phosphorylation, ribosome regulation, integrin-mediated adhesion, and glycolysis enzymes. However, the right atrium had more pronounced deficits in the TCA cycle and branched chain amino acid metabolism. Thus, these data highlight metabolic pathways that could be evaluated to selectively enhance right atrial function.
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Prins et al. (2026) studied Right heart failure (n=8). Pulmonary artery banding vs. Control was evaluated on Proteomic alterations in the right atrium and right ventricle. Pulmonary artery banding in pigs induced shared proteomic alterations in both right heart chambers, while the right atrium exhibited specific downregulation of the TCA cycle and BCAA metabolism.
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