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An automated system for the optimization of experimental conditions was applied to the reaction of carboxylic acid. This system consists of a laboratory robotic system, a spectrophotometer, and a personal computer which are interfaced with each other. The optimum conditions were obtained according to the super modified simplex algorithm. This model reaction involved 3 or 4 parameters, and was optimized after 28 experiments at most. The effects of the initial simplex as well as the feasibility and efficiency of the system are discussed.
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Matsuda et al. (1988) studied this question.
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