August 24, 2023Phlebology The Journal of Venous Disease
Biomarkers and the post-thrombotic syndrome: A systematic review of biomarkers associated with the occurrence of the post-thrombotic syndrome after lower extremity deep venous thrombosis
Key result
In a systematic review of 15 prospective studies, biomarkers such as D-dimer, ICAM-1, and IL-10 were consistently associated with the development of post-thrombotic syndrome after DVT.
Why the study?
Post-thrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis (DVT), and biomarkers are potentially valuable clinical tools for managing PTS.
Which biomarkers are associated with the development of post-thrombotic syndrome in adults with lower extremity deep venous thrombosis?
Population
Adults with lower extremity DVT across 15 prospective studies
Comparison
Various biomarkers associated with development of PTS
Design
Systematic review of prospective studies
Authors
Discussion
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Implication
Biomarker associations with PTS remain hypothesis-generating; leaves open clinical utility pending prospective validation.
Study Design
Type
Systematic Review
Structured PICO
Which biomarkers are associated with the development of post-thrombotic syndrome in adults with lower extremity deep venous thrombosis?
P
Population
Systematic review of 15 prospective studies evaluating biomarkers associated with the development of post-thrombotic syndrome in adults with lower extremity deep venous thrombosis.
E
Exposure
Biomarker assessment (including D-dimer, CRP, IL-6, ICAM-1, IL-10, adiponectin, tPA, HRG, TAFI, MMP-1/8, TIMP-1/2)
O
Outcome
Development of post-thrombotic syndrome (PTS) assessed by clinical scales (e.g., Villalta scale)surrogate
D-dimer, ICAM-1, and IL-10 emerge as promising biomarkers for predicting post-thrombotic syndrome after lower extremity DVT, though standardized research frameworks are needed.
Limitations
- Significant differences in study designs made it difficult to draw reliable conclusions regarding individual biomarkers.
- Significant differences in study designs
- Varied methods of data analysis
Cite This Study
Harbsmeier et al. (2023) conducted a systematic review in Post-thrombotic syndrome after lower extremity deep venous thrombosis. Biomarkers (e.g., D-dimer, ICAM-1, IL-10) was evaluated on Development of post-thrombotic syndrome. In a systematic review of 15 prospective studies, biomarkers such as D-dimer, ICAM-1, and IL-10 were consistently associated with the development of post-thrombotic syndrome after DVT.