Potentiometric Determination of Imatinib under Batch and Flow Injection Analysis Conditions

A new potentiometric electrochemical sensor (ion-selective electrode) based on the formation of ion associate of Imatinib mesylate with sodium tetraphenyl borate in polyvinyl chloride plactisized with dioctylphythalate was developed .Such electrode was prepared for the assay of the cited drug in its pure form and pharmaceutical formulations under batch and flow injection analysis conditions. The life span of the electrode is 30 days on continuous soaking and several months when kept in dry conditions. It is characterized by usable concentration range of (1.0 × 10-5-1.0 × 10-3 M) and (5.0 × 10-6-1.0 × 10-2 M) in batch and FIA conditions, respectively. The change of pH does not affect the potential reading or peak heights of the electrode in the range of 4.00-7.50 in batch condition. While in FIA, the peak heights representing the pH are almost stable in the range 4.00-6.00. The electrode is highly selective towards many inorganic cations, and neutral molecules. The obtained results indicated high accuracy and precision of the studied electrode as sensor for the drug.