Key result
3.0-T k-t SENSE perfusion MRI matches 1.5-T diagnostic accuracy for coronary stenosis, with improved image quality.
Observational (n=51)
No
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PURPOSE: To determine the feasibility and diagnostic accuracy of high-spatial-resolution myocardial perfusion magnetic resonance (MR) imaging at 3.0 T by using k-space and time (k-t) domain undersampling with sensitivity encoding (SENSE), or k-t SENSE. Data were compared with results of k-t SENSE-accelerated high-spatial-resolution perfusion MR imaging at 1.5 T and standard-resolution acquisition at 3.0 T. MATERIALS AND METHODS: The study was reviewed and approved by the local ethics review board; informed consent was obtained. k-t SENSE perfusion MR imaging was performed at 1.5 and 3.0 T (fivefold k-t SENSE acceleration; spatial resolution, 1.3 x 1.3 x 10 mm). Fourteen volunteers were studied at rest; 37 patients were studied during adenosine-induced stress. In volunteers, comparison was also made with standard-resolution (2.5 x 2.5 x 10 mm) twofold SENSE perfusion MR imaging results at 3.0 T. Image quality, artifact scores, signal-to-noise ratios (SNRs), and contrast enhancement ratios were derived. In patients, diagnostic accuracy of visual analysis to detect stenosis of more than 50% narrowing in diameter at quantitative coronary angiography was determined by using receiver operator characteristic (ROC) analysis. RESULTS: In volunteers, image quality and artifact scores were similar for 3.0- and 1.5-T k-t SENSE perfusion MR imaging, while SNR was higher (11.6 vs 5.6) and contrast enhancement ratio was lower (1.1 vs 1.5, P = .012) at 3.0 T. Compared with standard-resolution perfusion MR imaging, image quality was higher for 3.0-T k-t SENSE (3.6 vs 3.1, P = .04), endocardial dark rim artifacts were reduced (artifact thickness, 1.6 vs 2.4 mm, P < .001), and contrast enhancement ratios were similar. In patients, areas under the ROC curve for detection of coronary stenosis were 0.89 and 0.80 (P = .21) for 3.0 and 1.5 T, respectively. CONCLUSION: k-t SENSE-accelerated high-spatial-resolution perfusion MR imaging at 3.0 T is feasible, with similar artifacts and diagnostic accuracy as those at 1.5 T. Compared with standard-resolution twofold SENSE perfusion MR imaging, image quality at k-t SENSE MR imaging is improved and artifacts are reduced.
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Plein et al. (2008) conducted an observational in Coronary artery stenosis (n=51). 3.0-T k-t SENSE high-spatial-resolution myocardial perfusion MR imaging vs. 1.5-T k-t SENSE perfusion MR imaging and standard-resolution 3.0-T twofold SENSE perfusion MR imaging was evaluated on Diagnostic accuracy (area under the ROC curve) to detect coronary stenosis >50% diameter narrowing at quantitative coronary angiography (AUC 0.89 vs 0.80, p=0.21). 3.0-T k-t SENSE perfusion MRI showed similar diagnostic accuracy to 1.5-T for coronary stenosis (AUC 0.89 vs 0.80, P=0.21) and improved image quality vs standard 3.0-T (3.6 vs 3.1, P=0.04).
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