Relationship between intraoperative mean arterial pressure and acute kidney injury after robot-assisted laparoscopic prostatectomy

We aimed to investigate the relationship between intraoperative mean arterial pressure (MAP) and acute kidney injury (AKI) occurrence after robot-assisted laparoscopic prostatectomy (RALP), as well as the relationship between MAP and the maximal increase in serum creatinine (SCr) levels. We retrospectively evaluated the medical records of 750 patients who underwent RALP. The average real variability (ARV)-MAP, standard deviation (SD)-MAP, time-weighted average (TWA)-MAP, area under threshold (AUT)-65 mmHg, and area above threshold (AAT)-120 mmHg were calculated using MAPs collected within a 10-s interval. Eighteen (2.4%) patients developed postoperative AKI. None of the five MAP parameters could predict postoperative AKI, with the area under the receiver operating characteristic curve values for ARV-MAP, SD-MAP, TWA-MAP, AUT-65 mmHg, and AAT-120 mmHg being 0.561 (95% confidence interval [CI], 0.424–0.697), 0.561 (95% CI, 0.417–0.704), 0.584 (95% CI, 0.458–0.709), 0.590 (95% CI, 0.462–0.718), and 0.626 (95% CI, 0.499–0.753), respectively. ARV-MAP (per 15-mmHg/min increase) and TWA-MAP (per 30-mmHg increase) were positively correlated with delta-SCr levels (β = 0.21, P = 0.010 and β = 0.14, P = 0.002; respectively). However, the resulting increases did not cause AKI. Therefore, intraoperative MAP changes may not be a determining factor for AKI after RALP.