Key result
Antiarrhythmic medications frequently cause gastrointestinal side effects, including hepatotoxicity and pancreatitis, which are common reasons for drug discontinuation.
Knowledge of the gastrointestinal side effects of antiarrhythmic drugs is crucial for clinicians, as these adverse events frequently lead to treatment discontinuation.
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Clinicians should anticipate GI side effects to reduce antiarrhythmic discontinuation; narrative review extends awareness but leaves open prospective management data.
Antiarrhythmic drugs are commonly prescribed cardiac drugs. Due to their receptor mimicry with several of the gastrointestinal tract receptors, they can frequently lead to gastrointestinal side effects. These side effects are the most common reasons for discontinuation of these drugs by the patients. Knowledge of these side effects is important for clinicians that manage antiarrhythmic drugs. This review focuses on the gastrointestinal side effects of these drugs and provides a detailed up-to-date literature review of the side effects of these drugs. The review provides case reports reported in the literature as well as possible mechanisms that lead to gastrointestinal side effects.
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Amjad et al. (2017) conducted a review in Arrhythmias. Antiarrhythmic medications was evaluated. Antiarrhythmic medications frequently cause gastrointestinal side effects, including hepatotoxicity and pancreatitis, which are common reasons for drug discontinuation.
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