Cultures of Escherichia coli and Pseudomonas aeruginosa have been submitted to different ceftazidime concentrations (from 1 to 500 mg/l). A continuous monitoring of the culture was made with the MS-2 system. Phase contrast microscopy was used for study of bacterial morphology. The data obtained showed: for E. coli a drop in optical density and formation of round forms at concentrations close to the minimum inhibitory concentration (MIC) and for Ps. aeruginosa, a residual growth at all concentrations tested during the first 2 h. This corresponded to filament formation. These observations might have clinical implications concerning the mode of administration of the antibiotic, i.e., bolus or continuous infusion.
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Yourassowsky et al. (1981) studied this question.