Why the study?
Does transplacental or postnatal digoxin administration convert intrauterine supraventricular tachyarrhythmias to normal sinus rhythm in fetuses and newborns?
Does transplacental or postnatal digoxin administration convert intrauterine supraventricular tachyarrhythmias to normal sinus rhythm in fetuses and newborns?
Transplacental and postnatal digoxin therapy appears effective for converting fetal supraventricular tachyarrhythmias to normal sinus rhythm, yielding a good prognosis with maintenance therapy.
Six newborn infants with intrauterine supraventricular tachyarrhythmias (five cases of atrial flutter and one of supraventricular tachycardia) are described. Transplacental digitalisation was attempted in three cases. Supraventricular tachycardia associated with hydrops fetalis, detected in a fetus at a gestation of 31 weeks, was successfully converted to normal sinus rhythm eight days after the mother began treatment with digoxin. The serum concentration of digoxin in cord blood almost equalled the maternal concentration in three cases. In the remaining three cases treatment with digitalis was effective in converting tachyarrhythmias to sinus rhythm after delivery. With maintenance digoxin therapy, the prognosis of fetal tachyarrhythmias seems to be good, once conversion to sinus rhythm has been accomplished.
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Nagashima et al. (1986) studied this question.
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