ACI rats, 15 males and 15 females, were fed a diet containing 1% dextran sulfate sodium for 660 days. Twenty two of 29 surviving rats developed intestinal tumors between 288 and 660 days. Most tumors consisted of papillomas, and 4 squamous cell carcinomas were also induced, in addition to adenomas and adenocarcinomas. No intestinal tumors were observed in rats of the control group.
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Hirono et al. (1982) studied this question.