Key result
Patients with moderate to severe aortic valve regurgitation had significantly decreased central superficial capillary plexus density compared to healthy controls (17.00 vs 18.78, P≤0.05).
Why the study?
The study was conducted to assess retinal vessel density across the superficial capillary, deep capillary, and choriocapillaris plexus layers using optical coherence tomography angiography in patients with aortic valve regurgitation.
Does moderate to severe aortic valve regurgitation reduce retinal vascular density compared to healthy controls?
Cross-Sectional (n=76)
No
Does moderate to severe aortic valve regurgitation reduce retinal vascular density compared to healthy controls?
Patients with moderate to severe aortic regurgitation exhibit significantly decreased retinal vascular density and central macular thickness, suggesting impaired microperfusion.
Retinal OCTA changes in AR should not yet alter practice; leaves open noninvasive systemic perfusion monitoring in prospective studies.
Background: The aim of this study was to assess retinal vessel density in the superficial capillary plexus layer, deep capillary plexus layer and choriocapillaris plexus layer in patients with aortic valve regurgitation (AR) using optical coherence tomography angiography (OCTA). Methods: Thirty-eight healthy participants (group 1) and 38 patients with AR (group 2) were assessed for this study. Diagnosis of AR is made by transthoracic echocardiography (TTE). Severity of AR was assessed according to values in the 2014 American Heart Association/American College of Cardiology (AHA/ACC) valve guideline. Superficial capillary plexus density (SCPD), deep capillary plexus density (DCPD) and choriocapillaris plexus density (CCPD) were analyzed between groups using OCTA. Results: SCPD measurements were found to be decreased in the nasal, inferior and central regions of patients with AR (P ≤ 0.05). DCPD measurements were found to be decreased in the nasal and inferior regions of patients with AR (P ≤ 0.05). CCPD measurements were found to be decreased in the inferior and central regions of patients with AR (P ≤ 0.05). In patients with AR, CCPD measurements were significantly decreased in the inferior region compared to the control group. Central macular thickness was found to be significantly decreased in the patients with AR. Conclusions: Patients with AR showed decreased flow density compared with healthy controls. Retinal perfusion measured using OCTA in patients with AR may give an idea about microperfusion.
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Topaloğlu et al. (2023) conducted a cross-sectional in Aortic valve regurgitation (n=76). Aortic valve regurgitation vs. Healthy controls was evaluated on Central superficial capillary plexus density (SCPD) (p=≤0.05). Patients with moderate to severe aortic valve regurgitation had significantly decreased central superficial capillary plexus density compared to healthy controls (17.00 vs 18.78, P≤0.05).
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