Potential drug interaction among patients with depression: A systematic review

Introduction: Depression is a common mental disorder that has serious negative effects on individuals' quality of life.Given the increasing prevalence of depression and the complexities of its treatment, examining drug interactions in patients with this disorder is of particular importance.This study aims to systematically investigate common drug interactions in the treatment of depression and their implications in the Iranian population.Materials and Methods: This study was designed as a systematic review based on the PRISMA statement principles.Keywords related to depression and drug interactions were searched in both domestic and international databases such as Google Scholar and PubMed.Out of 81 initial articles, 52 were examined, and after excluding irrelevant papers, 3 final articles that investigated drug interactions in patients with depression were selected.Results: One study examined outpatient prescriptions (3,000 prescriptions) and two studies analyzed hospitalized patients (1,257 records) regarding drug interactions.Reported rates of drug interactions varied widely, ranging from 22.4% to 99.9%.Most interactions involved the concurrent use of multiple antidepressants, particularly those from the tricyclic antidepressant class, and were classified as serious.Conclusion: This study revealed the limited number of investigations into the prevalence and types of drug interactions in patients with depression in Iran, pointing to the need for further research in this field.