Glycogen Storage in the Liver in Diabetes Mellitus

In this clinic, where 800 patients are seen, we have noted what appears to be a new syndrome. It occurs in young, severe, " brittle" diabetics, and is characterized by two predominant features-an enlarged liver found to be full of glycogen and a constant tendency to hypoglycaemia while taking insulin. The enlarged liver, not unusual in diabetes mellitus and commonly supposed to be due to deposition of fat, was in each case found by repeated biopsy to be distended with masses of glycogen, as in von Gierke's disease.