Minimum inhibitory concentration (MIC) studies were conducted to observe synergistiC., antagonistic or additive effects produced by combinations of butylparaben, ethanol, potassium sorbate and sodium metabisulfite against growth of two Saccharomyces cerevisiae strains (Montrachet 522 and NCSU 76) in yeast nitrogen base‐glucose broth at pH 3.30. Results suggested antagonistic effects between SO 2 /sorbate, SO 3 /butylparaben and butylparaben‐ethanol. Additive effects were observed between ethanol/sorbate, ethanol/SO 2 , and butylparaben/sorbate. No synergistic effects were detected. NCSU 76 had higher MICs than Montrachet 522 for all individual antimicrobial agents indicating greater resistance to these compounds. On an individual molar basis, MIC results indicated butylparaben was more inhibitory than the other antimicrobial agents alone.
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Parish et al. (1988) studied this question.
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