Key result
In patients with septic shock, low-dose hydrocortisone was associated with a lower incidence of atrial fibrillation compared to no hydrocortisone (16.8% vs 28.8%; difference -11.9%; P=0.040).
Why the study?
Does low-dose hydrocortisone reduce the incidence of atrial fibrillation in patients with septic shock?
Cohort (n=261)
Yes
Does low-dose hydrocortisone reduce the incidence of atrial fibrillation in patients with septic shock?
Effect estimate: difference -11.9% (95% CI -23.4 to -0.5)
Absolute Event Rate: 16.8% vs 28.8%
Absolute Risk Reduction: 11.9%
p-value: p=.040
Low-dose hydrocortisone is associated with a significantly lower risk of developing new-onset atrial fibrillation in patients with septic shock.
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Low-dose hydrocortisone was associated with lower AF risk in septic shock; hypothesis-generating and should not yet change practice.
Launey et al. (2017) conducted a cohort in septic shock (n=261). Low-dose hydrocortisone vs. No hydrocortisone was evaluated on Incidence of atrial fibrillation (difference -11.9%, 95% CI -23.4 to -0.5, p=.040). In patients with septic shock, low-dose hydrocortisone was associated with a lower incidence of atrial fibrillation compared to no hydrocortisone (16.8% vs 28.8%; difference -11.9%; P=0.040).
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