Key result
Balloon pulmonary valvuloplasty significantly reduced the peak-to-peak systolic pressure gradient across the pulmonary valve from 76.5 to 32.0 mmHg (p<0.001).
Why the study?
Does balloon pulmonary valvuloplasty improve right ventricular peak pressure and peak-to-peak systolic pressure gradient in children with moderate to severe pulmonary stenosis?
Cohort (n=70)
No
Does balloon pulmonary valvuloplasty improve right ventricular peak pressure and peak-to-peak systolic pressure gradient in children with moderate to severe pulmonary stenosis?
Absolute Event Rate: 32% vs 76.5%
p-value: p=<0.001
Balloon pulmonary valvuloplasty is a safe and effective procedure for immediately reducing right ventricular peak pressure and transvalvular gradients in children with moderate to severe pulmonary stenosis.
Introduction: Balloon pulmonary valvuloplasty (BPV) has become the treatment of choice for the relief of moderate to severe pulmonary stenosis (PS). Objective: To assess the immediate outcome of BPV in children with congenital PS at Shahid Gangalal National Heart Centre (SGNHC), Kathmandu, Nepal. Methods: A retrospective longitudinal cohort study was carried out in SGNHC from June 2006 to June 2013. Seventy consecutive patients (37 males) with moderate to severe PS who underwent balloon valvuloplasty were included in the study. The gradient was measured pre and immediate post valvuloplasty at catheterization and compared. Results: After BPV, significant reductions in the right ventricular peak pressure from 111.3±43.2 mmHg to 57.0±25.9 mmHg (p <0.001) and peak-to-peak systolic pressure gradient across the pulmonary valve from 76.5±25.1 mmHg to 32.0±20.9 mmHg (p <0.001) were achieved. In 74.2% patients, peak-to-peak systolic pressure gradient across the pulmonary valve decreased below 35 mmHg. No major complication or mortality was noted. Conclusions: The immediate outcome of balloon pulmonary valvuloplasty in children was excellent.Sri Lanka Journal of Child Health, 2014; 43(2): 97-99(Keywords: Pulmonary stenosis; balloon pulmonary valvuloplasty; children)DOI: http://dx.doi.org/10.4038/sljch.v43i2.7011
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Adhikari et al. (2014) conducted a cohort in moderate to severe pulmonary stenosis (n=70). Balloon pulmonary valvuloplasty vs. Pre-valvuloplasty baseline was evaluated on peak-to-peak systolic pressure gradient across the pulmonary valve (p=<0.001). Balloon pulmonary valvuloplasty significantly reduced the peak-to-peak systolic pressure gradient across the pulmonary valve from 76.5 to 32.0 mmHg (p<0.001).
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