Both lipase PS and Novozym 435 promote the ring-opening polymerization of lacOCA, the O-carboxylic anhydride derived from lactic acid. Accordingly, PLA of relatively high molecular weights (M(n) up to 38400 g/mol) and low polydispersities (M(w)/M(n) < 1.4) are obtained in high yields within a few hours at 80 degrees C. Slight preference for l-lacOCA over d-lacOCA is observed, and with Novozym 435, the molecular weight of the obtained PLA can be controlled by varying the lipase loading.
No takes yet. Share an insight, caveat, or question.
Bonduelle et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: