Cellular Focal Segmental Glomerulosclerosis: A Controversial Pathological Entity. Its Pathogenesis and Therapeutic Basis

Cellular FSGS variant was described in 1980 and it was incorporated in diagnostic algorithm of Columbia Classification in 2004. This type of FSGS must show several diagnostic pathological criteria. This review highlights the key features of FSGS cellular variant in relation to histopathological changes, the differential diagnosis and discusses about pathogenesis and therapeutic advances. Although FSGS cellular variant is a recognized category in Columbia Classification it is remained as a controversial renal pathology, and it is observation open the possibility to consider other pathological diagnosis.