Key result
The NLRP3 inflammasome is an effective therapeutic target for reducing the risk of coronary artery disease and its complications, with colchicine becoming the first anti-inflammatory drug in guidelines.
Why the study?
Considering colchicine in routine clinical practice requires cardiologists to understand the basic molecular mechanisms of inflammation and the NLRP3 inflammasome in cardiovascular diseases.
Answers are grounded in this paper and cite their sources.
Understanding the molecular mechanisms of the NLRP3 inflammasome is essential for cardiologists as anti-inflammatory drugs like colchicine enter routine clinical practice for the secondary prevention of cardiovascular events.
Within five years after myocardial infarction (MI), a third of patients have secondary major adverse cardiovascular events (MACEs). The first randomized clinical trials to show the effectiveness of anti-inflammatory strategies in the prevention of MACEs are CANTOS, COLCOT and LoDoCo2. These studies have identified an effective therapeutic target — the NLRP3 inflammasome. The results of COLCOT and LoDoCo2 led to colchicine becoming the first anti-inflammatory drug to be included in clinical guidelines for the treatment of patients with coronary artery disease (CAD). However, considering colchicine in routine clinical practice requires the cardiologist to have knowledge of the basic molecular mechanisms of inflammation in cardiovascular diseases. The review discusses current data on inflammation and the NLRP3 inflammasome in the pathogenesis of CAD and MI, results and issues of their application in clinical cardiology.
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Ryabov et al. (2023) conducted a review in Acute myocardial infarction, coronary artery disease. Anti-inflammatory therapy (Colchicine, Canakinumab) was evaluated. The NLRP3 inflammasome is an effective therapeutic target for reducing the risk of coronary artery disease and its complications, with colchicine becoming the first anti-inflammatory drug in guidelines.
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