Key result
The eNOS/NOS3 rs1799983_GT polymorphism was independently associated with a significantly increased risk of coronary microvascular dysfunction (OR 5.234).
Why the study?
Do genetic polymorphisms of ion channels correlate with ischemic heart disease and coronary microvascular dysfunction in patients undergoing coronary angiography?
Population
242 consecutive patients who were candidates for coronary angiography
Design
Cohort
Authors
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Hypothesis-generating for eNOS rs1799983 in CMD; prospective validation needed before clinical risk stratification.
Observational (n=242)
No
Do genetic polymorphisms of ion channels correlate with ischemic heart disease and coronary microvascular dysfunction in patients undergoing coronary angiography?
Odds Ratio: 5.234 (95% CI 1.26–8.521)
p-value: p=0.023
Genetic polymorphisms in specific ion channels (eNOS, Kir6.2, Nav1.5) may influence susceptibility to coronary microvascular dysfunction and ischemic heart disease independent of classic cardiovascular risk factors.
Fedele et al. (2013) conducted an observational in Ischemic heart disease and coronary microvascular dysfunction (n=242). eNOS/NOS3 rs1799983_GT polymorphism vs. Absence of polymorphism / Normal coronary arteries was evaluated on Microvascular dysfunction (OR 5.234, 95% CI 1.260-8.521, p=0.023). The eNOS/NOS3 rs1799983_GT polymorphism was independently associated with a significantly increased risk of coronary microvascular dysfunction (OR 5.234).
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