Implantation of the human embryo into the uterine lining is a crucial step during early pregnancy, yet little is known about the molecular mechanisms involved. In their Perspective, Fazleabas and Kim discuss new work (Genbacev et al .) identifying L-selectin expressed by trophoblast cells of the blastocyst as a crucial mediator of the initial interaction between the embryo and uterine lining, the first step in implantation.
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Fazleabas et al. (2003) studied this question.
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