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SUMMARY: Results from hundreds of genome-wide association studies (GWAS) are now freely available and offer a catalogue of the association between phenotypes across medicine with variants in the genome. With the aim of using this data to better understand therapeutic mechanisms, we have developed Drug Targetor, a web interface that allows the generation and exploration of drug-target networks of hundreds of phenotypes using GWAS data. Drug Targetor networks consist of drug and target nodes ordered by genetic association and connected by drug-target or drug-gene relationship. We show that Drug Targetor can help prioritize drugs, targets and drug-target interactions for a specific phenotype based on genetic evidence. AVAILABILITY AND IMPLEMENTATION: Drug Targetor v1.21 is a web application freely available online at drugtargetor.com and under MIT licence. The source code can be found at https://github.com/hagax8/drugtargetor. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Gaspar et al. (2018) studied this question.
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