Key result
A 79-year-old man taking dabigatran developed an extremely elevated PT-INR of 12.6 without bleeding symptoms, which normalized after discontinuing the medication.
Case Report (n=1)
Dabigatran can cause extremely elevated PT-INR in the setting of acute kidney injury, highlighting the potential utility of coagulation monitoring in high-risk patients.
Dabigatran may cause extreme PT-INR elevation in mild renal impairment; this case report leaves open monitoring implications.
Background: We present the case of a patient who was administered dabigatran and showed an extremely elevated prothrombin time-international normalized ratio (PT-INR).Case report: A 79-year-old man was referred due to PT-INR 12.6. The patient was taking 110 mg of dabigatran twice daily in capsule form. On admission, blood urea nitrogen level was 23 mg/dL, creatinine was 1.51 mg/dL, and the estimated glomerular filtration rate was 44.8 mL/min/1.73 m2. Coagulation tests revealed PT 96.8 seconds, PT-INR 12.46, and activated partial thromboplastin time 125.5 seconds. Dabigatran was discontinued, PT-INR on the day after admission was 8.96. PT-INR recovered to 1.61 on the fourth day without any treatment.Conclusion: The PT-INR was not directly correlated with dabigatran activity. Regular monitoring of coagulation was not necessary in all patients taking dabigatran. However, it may be useful to regularly perform coagulation tests in patients with renal impairment or in those at a high risk of bleeding.
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Kim et al. (2023) conducted a case report in Nonvalvular atrial fibrillation (n=1). Dabigatran etexilate was evaluated on PT-INR. A 79-year-old man taking dabigatran developed an extremely elevated PT-INR of 12.6 without bleeding symptoms, which normalized after discontinuing the medication.
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