Key result
Treatment with 6 cycles of R-CHOP chemotherapy led to the complete disappearance of the hypermetabolic right atrial mass in a patient with primary cardiac diffuse large B-cell lymphoma.
Why the study?
Primary cardiac non-Hodgkin lymphoma is a rare tumor accounting for 1.3% of cardiac neoplasia with very poor prognosis if untreated, and there is no defined treatment for this condition.
Case Report (n=1)
No
Primary cardiac lymphoma can present with minimal symptoms and requires prompt multimodality imaging and biopsy for diagnosis and initiation of chemotherapy.
Alerts clinicians to primary cardiac lymphoma in right atrial masses; leaves open optimal management strategies.
BACKGROUND: Primary cardiac non-Hodgkin's lymphoma is rare tumor, accounting for 1.3% of cardiac neoplasia, with very poor prognosis if untreated. CASE SUMMARY: A 68-year-old man with dyslipidemia presented with 3 weeks of dyspnea and 2 months of chronic cough, and was tachypneic without hemodynamic instability. Computed tomography scan and transthoracic echocardiography showed a 74 × 56-mm right atrial mass attached to the interatrial septum, and was invading the vena cava and compressing the right superior pulmonary vein. Biopsy confirmed a diagnosis of high-grade lymphoma B. Prednisone and chemotherapy (R-CHOP) were initiated. Follow-up computed tomography scan showed reduced mass and less compression of the superior vena cava. DISCUSSION: Primary cardiac lymphoma is an extremely rare tumor. Only a handful of cases have been described. There is no defined treatment for this condition.
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Fournier et al. (2025) conducted a case report in Primary cardiac lymphoma (n=1). R-CHOP chemotherapy was evaluated on Tumor response. Treatment with 6 cycles of R-CHOP chemotherapy led to the complete disappearance of the hypermetabolic right atrial mass in a patient with primary cardiac diffuse large B-cell lymphoma.
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