Comparative study demonstrates chemical vanadium catalysis yields lower environmental impact than algal bromoperoxidase in aqueous thymol bromination, highlighting greener synthetic routes.
The catalytic activity of the vanadium‐dependent bromoperoxidase isolated from the brown alga Ascophyllum nodosum is compared with the activity of a cheap, commercially available V‐catalyst precursor in the bromination of thymol. Organic solvents have been avoided to make the system appealing from a sustainable chemistry point of view. It is noteworthy that, notwithstanding the low solubility of the substrate, the thymol bromination reactions were performed in water, with a safe brominating source, under mild conditions, and with relatively inexpensive reagents. In this regard, the greenness of the systems was evaluated by the estimation of the E ‐factor value; the result is that the chemical reaction has a lower environmental impact than the enzymatic process, with an E ‐factor in the range of eco‐friendly processes.
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Sabuzi et al. (2015) studied this question.
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