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Staphylococcus aureus, strain SAB2, synthesized hyaluronidase in a chemically denned medium only in the presence of tyrosine and tryptophan, even though these amino acids were not required for optimal growth. Glycine was indispensable for growth of this organism. Supplementation of the synthetic medium with glycyl-L-tyrosine or glycyl-L-tryptophan enhanced both growth and hyaluronidase production.
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Stephan E. Mergenhagen (1958) studied this question.
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