The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats.

Figures

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  Fig. 1. Comparison of the numbers of central (A) and total (B) crossing in the OF test among the four groups. Data are expressed as mean ± SEM (n = 10 in each group). **p < 0.01 shows the difference between sham and control groups. +++ p < 0.001 shows the difference between Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups compared to the sham group. $$ p < 0.01 $$$ p < 0.001 shows the difference between Capto 50-LPS and Capto 100-LPS groups compared to the Capto 10-LPS group

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  Fig. 2. Comparison of the number of entries to (A) and the time spent in (B) the open arm of the EPM test across the four groups. Data are expressed as mean ± SEM (n = 10 in each group). *** p < 0.001 indicate the difference between sham and control groups. ++ p < 0.01 +++ p < 0.001 indicate the difference between Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups compared to the sham group. $$ p < 0.01 $$$ p < 0.001 indicate the difference between Capto 50-LPS and Capto 100-LPS groups compared to the Capto 10-LPS group. ### p < 0.001 indicates the difference between Capto 100-LPS and Capto 50- LPS groups

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  Fig. 3. Comparison of immobility (A) and active (B) time in the FS test across the four groups. Data are expressed as mean ± SEM (n=10 in each group). *** p < 0.001 shows the difference between control and sham groups. +++ p < 0.001 shows the difference between Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups compared to the control group

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  Fig. 4. Comparison of serum interleukin-6 levels among the four groups. Data are expressed as mean±SEM (n = 10 in each group). *** p < 0.001 indicates the difference between control and sham groups. +++ p < 0.001 indicates the difference between Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups compared to the control group. $$$ p < 0.001 indicates the difference between Capto 50-LPS and Capto 100-LPS groups compared to the Capto 10-LPS group. ## p < 0.01 indicates the difference between Capto 100-LPS and Capto 50-LPS groups