Key result
Surgical antibiotic prophylaxis for thoracic operations showed low consistency with ASHP guidelines, including continuation for more than 24 hours post-surgery in 86.7% of cases.
Why the study?
Surgical antibiotic prophylaxis decreases surgical site infections, but inappropriate use can lead to resistance, prolonged hospital stay, and adverse drug reactions, prompting evaluation of guideline concordance in thoracic surgery.
What is the rate of concordance between surgical antibiotic prophylaxis administration and ASHP guidelines in thoracic operations?
Observational (n=222)
No
What is the rate of concordance between surgical antibiotic prophylaxis administration and ASHP guidelines in thoracic operations?
There is a relatively low rate of consistency between surgical antibiotic prophylaxis administration and ASHP guidelines in thoracic surgery in Iran, particularly regarding prolonged postoperative use.
Answers are grounded in this paper and cite their sources.
Low guideline concordance in this Iranian thoracic cohort warrants local stewardship audits; leaves open generalizability and outcome effects elsewhere.
Background Surgical antibiotic prophylaxis ( SAP ) decreases the incidence of surgical site infections. However, inappropriate use of prophylactic antibiotics may lead to antibiotic resistance, prolonged hospital stay and adverse drug reactions. Aim This prospective study aimed to assess the concordance of prophylactic antibiotic administration for thoracic operations in Iran with American Society of Health‐System Pharmacists ( ASHP ) guidelines. Methods The appropriateness of SAP administration in 222 thoracic operations was assessed in a respiratory referral centre over a period of 4 months. Demographic, clinical and SAP data were recorded from patient files. ASHP guidelines were used to evaluate the appropriateness of prophylactic antibiotic administration. Results Cefazolin was correctly prescribed for approximately 70% of patients who required antibiotic prophylaxis. SAP was administered at the correct time (within 60 min before surgery) for 71.6% of surgeries. Intraoperative doses were correctly given in 27.7% of prolonged procedures. In 86.7% of surgeries, antibiotic administration was continued for more than 24 h after surgery (based on a physician's opinion or recent microbiological cultures). Conclusion The results suggest a relatively low rate of consistency between SAP administration and ASHP guidelines in Iran. A long duration of antibiotic administration after operations is an important finding, which should be considered and re‐evaluated by thoracic surgeons in Iran.
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Shadmehr et al. (2019) conducted an observational in Thoracic surgery (n=222). Surgical antibiotic prophylaxis was evaluated on Appropriateness of surgical antibiotic prophylaxis administration according to ASHP guidelines. Surgical antibiotic prophylaxis for thoracic operations showed low consistency with ASHP guidelines, including continuation for more than 24 hours post-surgery in 86.7% of cases.
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