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Demonstrates increased sodium and water excretion from manidipine in spontaneously hypertensive rats, suggesting potential utility in treating hypertension.
Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (3 mg/kg). These results suggest that manidipine may be useful for treating hypertension.
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Nagaoka et al. (1989) studied this question.
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