Key result
Arterial stiffness and markers of renal impairment were independent predictors of cardiac and vascular modifications in stage III CKD, despite similar absolute LVMi and IMT values compared to stage II.
Why the study?
Does arterial stiffness measurement using echo-tracking predict subclinical cardiovascular remodeling in patients with moderate chronic kidney disease?
Cross-Sectional (n=141)
Does arterial stiffness measurement using echo-tracking predict subclinical cardiovascular remodeling in patients with moderate chronic kidney disease?
Arterial stiffness derived from echo-tracking provides incremental value over traditional risk factors in predicting cardiovascular remodeling in patients with stage III chronic kidney disease.
May refine remodeling risk assessment in stage III CKD; extends cross-sectional associations but leaves open prospective validation.
Cardiovascular remodeling in chronic kidney disease (CKD) is responsible for the high mortality found in this condition. A total of 89 consecutive outpatients with stage III CKD and 52 patients with stage II CKD with similar degree of traditional atherosclerotic risk factors underwent routine echocardiographic and carotid Doppler examination, evaluating vascular and cardiac remodeling (intima-media thickness [IMT] and left ventricular mass index [LVMi]), and its relation with arterial stiffness, determined in the same examination, using an echo-tracking technique. Also the absolute values of LVMi and IMT were statistically similar between the 2 groups, their determinants were completely different, only in stage III the markers of renal impairment and arterial stiffness being independent predictors of cardiac and vascular modifications. We concluded that macroanatomical measurements do not fully describe cardiovascular remodeling in this setting. Arterial stiffness echo-tracking derived could add valuable information, being an easy-to-perform parameter during a routine examination.
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Ticulescu et al. (2011) conducted a cross-sectional in Chronic kidney disease (n=141). Arterial stiffness and markers of renal impairment vs. Traditional atherosclerotic risk factors / Stage II CKD was evaluated on Vascular and cardiac remodeling (intima-media thickness and left ventricular mass index). Arterial stiffness and markers of renal impairment were independent predictors of cardiac and vascular modifications in stage III CKD, despite similar absolute LVMi and IMT values compared to stage II.
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