Population
Mouse embryonic fibroblasts, primary splenocytes from WT and MAVS-KO mice, and human peripheral blood…
Comparison
Chemically generated oxidative stress and… vs Untreated cells, MAVS-KO cells, cells expressing…
Design
Preclinical
Key result
Oxidative stress induced virus-independent MAVS oligomerization in systemic lupus erythematosus patients, which correlated with increased type I interferon production and mitochondrial dysfunction.
Authors
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Oxidative stress may drive IFN signatures via MAVS in SLE; leaves open therapeutic targeting pending validation.
Observational (n=34)
Oxidative stress-induced MAVS oligomerization contributes to the type I IFN signature in SLE, highlighting a potential therapeutic role for mitochondria-targeted antioxidants.
Buskiewicz et al. (2016) conducted an observational in Systemic lupus erythematosus (n=34). Oxidative stress vs. Healthy controls was evaluated on Spontaneous MAVS oligomerization in peripheral blood mononuclear cells. Oxidative stress induced virus-independent MAVS oligomerization in systemic lupus erythematosus patients, which correlated with increased type I interferon production and mitochondrial dysfunction.