Key result
Initiation of levothyroxine in the preceding 30 days was not associated with an increased risk of hospitalization for hemorrhage among older patients receiving warfarin (adjusted OR 1.11).
Why the study?
Does the initiation of levothyroxine increase the risk of hospitalization for hemorrhage in older patients receiving warfarin?
Population
260,076 older patients receiving warfarin
Comparison
Initiation of levothyroxine in the preceding 30… vs No initiation of levothyroxine in the preceding…
Design
Case-control
Authors
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No increased hemorrhage risk seen with levothyroxine initiation in older warfarin users; challenges interaction warnings but hypothesis-generating and should not change practice.
Case-Control (n=51,225)
Does the initiation of levothyroxine increase the risk of hospitalization for hemorrhage in older patients receiving warfarin?
Odds Ratio: 1.11 (95% CI 0.67–1.86)
Initiation of levothyroxine does not significantly increase the risk of hospitalization for hemorrhage in older patients on warfarin, challenging current drug interaction warnings.
Pincus et al. (2012) conducted a case-control in Patients receiving warfarin (n=51,225). Levothyroxine initiation vs. No new levothyroxine prescription was evaluated on Hospitalization for hemorrhage (adjusted OR 1.11, 95% CI 0.67-1.86). Initiation of levothyroxine in the preceding 30 days was not associated with an increased risk of hospitalization for hemorrhage among older patients receiving warfarin (adjusted OR 1.11).
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