Key result
Exercise training did not significantly change hs-cTnT or NT-proBNP levels compared with control, but higher baseline hs-cTnT was associated with blunted fitness improvement (β = -0.08).
Why the study?
hs-cTnT and NT-proBNP are commonly detected in adults with T2D and associate with heart failure risk, but the effects of exercise training on them and their link to cardiorespiratory fitness were unclear.
Does exercise training improve cardiac biomarkers (hs-cTnT and NT-proBNP) in adults with type 2 diabetes?
RCT (n=166)
Randomly assigned to one of 3 ET groups or a non-exercise control group
Does exercise training improve cardiac biomarkers (hs-cTnT and NT-proBNP) in adults with type 2 diabetes?
Exercise training does not significantly modify cardiac biomarkers in adults with type 2 diabetes, and higher baseline hs-cTnT predicts a blunted cardiorespiratory fitness response to exercise.
ET does not alter hs-cTnT or NT-proBNP in T2D; leaves open whether baseline hs-cTnT predicts fitness response.
High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are cardiac biomarkers commonly detected in adults with type 2 diabetes (T2D) and are associated with heart failure risk. The purpose of this study was to evaluate the effects of exercise training (ET) on hs-cTnT and NT-proBNP and evaluate the associations of these biomarkers with cardiorespiratory fitness among adults with T2D. Participants of the HART-D (Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes) trial who were randomly assigned to one of 3 ET groups or a non-exercise control group were included. Cardiac biomarkers and cardiorespiratory fitness (evaluated by peak oxygen uptake [VO2peak]) were assessed at baseline and after 9 months. The effects of ET (3 ET groups pooled) vs non-exercise control on hs-cTnT and NT-proBNP were assessed using separate analysis of covariance models. Multivariable-adjusted linear regression was performed to identify factors associated with follow-up biomarkers and ΔVO2peak. The present study included 166 participants randomized to the ET (n = 135) and non-exercise control (n = 31) groups. Compared with the non-exercise control, ET did not significantly change hs-cTnT or NT-proBNP. In adjusted analysis, each ET group and ΔVO2peak were not significantly associated with hs-cTnT or NT-proBNP levels on follow-up. Among individuals in the ET group, baseline hs-cTnT was inversely associated with ΔVO2peak [per 1 SD higher log (hs-cTnT): β = −0.08 (95% CI = −0.15 to −0.01)]. Among individuals with T2D, ET did not modify cardiac biomarkers. Higher baseline hs-cTnT was associated with blunted cardiorespiratory fitness improvement in response to exercise.
No takes yet. Share an insight, caveat, or question.
Patel et al. (2023) conducted an RCT in Type 2 Diabetes (n=166). Exercise training vs. Non-exercise control was evaluated on hs-cTnT and NT-proBNP levels. Exercise training did not significantly change hs-cTnT or NT-proBNP levels compared with control, but higher baseline hs-cTnT was associated with blunted fitness improvement (β = -0.08).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: