Key result
Among 146 Sudanese children with cardiomyopathy, dilated cardiomyopathy was the most common type (67%), and the overall hospital mortality rate was 20%.
Why the study?
Cardiomyopathy leads to significant mortality and morbidity, but data in Africa are limited.
Observational (n=146)
No
Pediatric cardiomyopathy in Sudan is predominantly of the dilated type, presents mostly as heart failure, and carries a high short-term mortality rate of 20%.
Provides initial Sudanese pediatric CMP data; leaves open etiology, management, and outcomes questions for prospective studies.
Cardiomyopathy (CMP) constitutes a group of diseases of heart muscle that lead to significant mortality and morbidity, with limited data in Africa. This study aims to describe clinical and echocardiographic (echo) patterns and short-term outcomes of Pediatric CMP. The study was carried at Gaafar Ibnauf Children's Hospital and included all children 0-18 years with an echo diagnosis of CMP. A retrospective part of the study was carried from January 2013 to 2019 and a prospective part from January to June 2019. Clinical and echo data were collected on presentation and on at least one follow up. A total of 146 patients were diagnosed with CMP during the study period. Most patients (48%) presented at 1-6 years of age, neonatal CMP was present in 4%. Familial incidence was detected in 11% of cases. Heart failure was the most common mode of presentation in 96% of patients; 65% needed hospitalisation; a third of them needed intensive care unit admission. The most common type of CMP was the dilated type (67%). Others included noncompaction CMP (19%), restrictive CMP and hypertrophic CMP (each of them in 6% of patients). Hospital mortality was 20% for the whole cohort and 100% for neonates. Other complications occurred in 21% of patients including arrhythmias, cerebrovascular accidents and end stage renal disease. Echo follow up showed that most patients (52%) remained the same, 26% worsened and 21% improved. Genetic and metabolic studies that could help to improve management and outcomes of CMP are needed.
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Mamoun et al. (2021) conducted an observational in Pediatric cardiomyopathy (n=146). Cardiomyopathy was evaluated on Hospital mortality. Among 146 Sudanese children with cardiomyopathy, dilated cardiomyopathy was the most common type (67%), and the overall hospital mortality rate was 20%.
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